Boiling (potentially responsive) grids down to their essence. Planning on stealing much of this, soon, for a music site near you.
If a more complex layout presents itself, people often reach for a grid framework. They assume grids are these super difficult things best left to super CSS nerds. That idea is perpetuated by the fact that a lot of the grid systems they reach for are very complicated.
I am a certified CSS nerd, but I’ve avoided rolling my own grids for just these reasons. To be fair, I reached that conclusion a few years ago when certain older browsers were still a non-fractional part of my sites’ visitors.
Life’s simpler in a post-IE7 world.